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KMID : 0383820110700030251
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Tuberculosis and Respiratory Diseases
2011 Volume.70 No. 3 p.251 ~ p.256
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A Case of Prothionamide Induced Hepatitis on Patient with Multi-Drug Resistant Pulmonary Tuberculosis
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Park Jun-Beom
Park Byung-Hoon
Son Ji-Young
Jung Ji-Ye
Kim Eun-Young
Lim Ju-Eun
Lee Sang-Hoon
Lee Sang-Kook
Kim Song-Yee
Jung Won-Jai
Lim Seung-Taek
Lee Kyung-Jong
Kang Young-Ae
Kim Young-Sam
Kim Se-Kyu
Chang Joon
Choi Jun-Jeong
Park Moo-Suk
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Abstract
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The prevalence of multi-drug resistant tuberculosis (MDR-TB), which is resistant to isoniazid and rifampin, has been increasing in Korea. And the side effects of 2nd line anti-tuberculosis medications, including drug-induced hepatitis, are well known. Although prothionamide (PTH) is one of the most useful anti-TB medications and although TB medication-induced acute hepatitis is a severe complication, there are only a few published case reports about prothionamide induced hepatitis. In this case report, a 22 year old male was diagnosed with pulmonary MDR-TB and was administered 2nd line anti-TB mediations, including PTH. Afterwards, he had a spiking fever and his liver enzymes were more than 5 times greater than the upper limit of the normal range. He was then diagnosed with drug-induced hepatitis by liver biopsy. His symptoms and liver enzyme elevation were improved after stopping PTH. Accordingly, we report this case of an association between PTH and acute hepatitis.
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KEYWORD
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Tuberculosis, Multidrug-Resistant, Hepatitis, Prothionamide
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